Table 2.
Cox Regression Models for Patient Survival*
| Predictor† | A2ALL & Non-A2ALL Combined |
A2ALL Only |
Non-A2ALL Only |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Hazard Ratio | P-value | 95% Confidence Limits | Interaction w/Center Type P-value‡ | Hazard Ratio | P-value | 95% Confidence Limits | Hazard Ratio | P-value | 95% Confidence Limits | |
| LDLT case ≤15 | 1.61 | <.0001 | 1.28 – 2.02 | 0.04 | 2.24 | <.0001 | 1.71 – 2.94 | 1.45 | 0.005 | 1.12 – 1.87 |
| Donor age per 10 yr | 1.13 | 0.0002 | 1.06 – 1.20 | 0.23 | 1.22 | 0.009 | 1.05 – 1.41 | 1.10 | 0.006 | 1.03 – 1.18 |
| Recipient age per 10 yr | 1.20 | 0.0003 | 1. 09 – 1.33 | 0.11 | 1.38 | 0.001 | 1.14 – 1.66 | 1.15 | 0.006 | 1.04 – 1.27 |
| Serum creatinine (ln) | 1.52 | <.0001 | 1.26 – 1.83 | 0.48 | 1.78 | 0.001 | 1.28 – 2.46 | 1.45 | 0.0007 | 1.17 – 1.79 |
| Diagnosis of HCV | 1.18 | 0.026 | 1.02 – 1.37 | 0.57 | 1.24 | 0.20 | 0.89 – 1.72 | 1.15 | 0.09 | 0.98 – 1.35 |
| Diagnosis of HCC | 2.12 | <.0001 | 1.68 – 2.69 | 0.52 | 1.86 | 0.013 | 1.15 – 3.02 | 2.30 | <.0001 | 1.77 – 2.95 |
| Recipient medical condition: | 0.39 | |||||||||
| ICU vs home | 2.52 | <.0001 | 1.87 – 3.41 | 0.18 | 1.53 | 0.19 | 0.81 – 2.87 | 2.89 | <.0001 | 2.02 – 2.99 |
| Hospitalized (no ICU) vs home | 1.62 | <.0001 | 1.32 – 1.98 | 0.64 | 1.36 | 0.19 | 0.86 – 2.16 | 1.67 | <.0001 | 1.32 – 4.14 |
| Cold ischemia time > 4.5hours¤ | 1.79 | 0.0006 | 1.28 – 2.50 | 0.34 | 2.15 | 0.006 | 1.24 – 3.73 | 1.77 | 0.010 | 1.15 – 2.73 |
*
Adjusted for center clustering using robust variances based on the sandwich estimator for Cox regression.
†
Variables tested but not significant included recipient weight, dialysis, ascites, donor weight, donor’s biological relationship to recipient, and transplant year.
‡
Interactions were tested one at a time in models including all main effects listed as predictors in the table above.
¤
Results for CIT are based on separate models with a smaller sample size because of missing CIT values in 33% of cases.