Table 3. Survival Hazard Ratios for Gene-Radiation Interactions among Radiation-Treated and Untreated Patients in Pancreatic Cancer.
| Gene | Variant | genotypes1 | HR (95%CI)2 | P interaction | |
|---|---|---|---|---|---|
| Treated | Untreated | ||||
| RRM1 | rs1662172 | AA/(AG+GG) | 2.18(1.44-3.31) | 0.90(0.67-1.21) | 0.00063 |
| IQGAP2 | rs153317 | CC/(CT+TT) | 2.33(1.43-3.80) | 1.13(0.80-1.46) | 0.0088 |
| TP73 | rs3765736 | CC/(CT+TT) | 0.60(0.40-0.90) | 1.00(0.76-1.33) | 0.040 |
| XRCC3 | rs861539 | CC/(CT+TT) | 1.74(1.13-2.67) | 1.06(0.82-1.37) | 0.050 |
1
Reference genotype/risk genotypes
2
Adjusted for age, sex, race, stage, and treatments except radiation