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. Author manuscript; available in PMC: 2012 Jun 15.
Published in final edited form as: Melanoma Res. 2011 Feb;21(1):35–43. doi: 10.1097/CMR.0b013e3283426805

Figure 4. Effects of GRP78 Immunization on B16F1 Flank Tumor Growth.

Figure 4

Panel A. Growth of 5×103 B16F1 cells implanted in the flanks of C57BL/6 mice. Average tumor volumes in GRP78-immunized mice (N=10) are represented by squares while those of adjuvant-only mice (N=9) are represented by circles. Data shown represent mean tumor volume in cm3 ± SEM versus day post-implantation. Asterisks represent statistically significant differences in mean tumor volume at a given timepoint (P<0.05, Student’s t-test). Panel B. Kaplan-Meier analysis of mouse survival compares GRP78-immunized mice to controls. The median survival for the two groups is 26 and 29 days, respectively (P<0.05, log-rank test). The GRP78-immunized group is represented by a solid line, while the adjuvant control group is represented by a dashed line.