Table 3.
Stratification analyses between the combined genotypes of MDM4 polymorphisms and SCCHN risk
| Variables | No. (Case / Control) | Combined genotypes (case / control)
|
OR (95% CI)b | |||
|---|---|---|---|---|---|---|
| 0 risk genotypea | 1–3 risk genotypesa | |||||
| n | % | n | % | |||
| Age (years) | ||||||
| ≤45 | 153 / 170 | 28 / 32 | 18.3 / 18.8 | 125 / 138 | 81.7 / 81.2 | 1.06 (0.59–1.87) |
| 46–60 | 525 / 523 | 108 / 109 | 20.6 / 20.8 | 417 / 414 | 79.4 / 79.2 | 1.06 (0.77–1.45) |
| >60 | 397 / 386 | 70 / 87 | 17.6 / 22.5 | 327 / 299 | 82.4 / 77.5 | 1.41 (0.97–2.05) |
| Sex | ||||||
| Female | 267 / 253 | 48 / 52 | 18.0 / 20.5 | 219 / 201 | 82.0 / 79.5 | 1.31 (0.81–2.09) |
| Male | 808 / 826 | 158 / 176 | 19.6 / 21.3 | 650 / 650 | 80.5 / 78.7 | 1.12 (0.87–1.43) |
| Smoking status | ||||||
| Never | 299 / 526 | 55 / 111 | 18.4 / 21.1 | 245 / 415 | 81.6 / 78.9 | 1.18 (0.82–1.69) |
| Ever | 776 / 553 | 151 / 117 | 19.46 / 21.2 | 625 / 436 | 80.54 / 78.8 | 1.11 (0.84–1.46) |
| Drinking status | ||||||
| Never | 294 / 468 | 52 / 102 | 17.7 / 21.8 | 242 / 366 | 82.31 / 78.2 | 1.29 (0.88–1.87) |
| Ever | 781 / 611 | 154 / 126 | 19.7 / 20.6 | 627 / 485 | 80.28 / 79.4 | 1.09 (0.83–1.44) |
a
This represents the number of risk genotypes: rs11801299GG, rs1380576CG+GG, and rs10900598GG.
b
Adjusted for age, sex, smoking status, and alcohol use in a logistic regression model.