Table 4.

Association between the combined genotypes of MDM4 polymorphisms and SCCHN risk stratified by tumor sites

Genotypes	Oropharynx				Oral cavity			Larynx and Hypopharynx
	Control (n = 1,079)	Case (n = 546)	P	OR (95% CI)a	Case (n = 315)	P	OR (95% CI)a	Case (n = 214)	P	OR (95% CI) a
rs11801299
GG	665	305	0.110c	1.00	191	0.600c	1.00	138	0.690c	1.00
AG	376	165		0.80 (0.63–1.01)	116		1.07 (0.81–1.42)	70		0.87 (0.61–1.24)
AA	38	26		1.24 (0.73–2.11)	8		0.65 (0.29–1.49)	6		0.54 (0.20–1.43)
AG+AA	414	191	0.182d	0.84 (0.67–1.05)	124	0.749d	1.03 (0.79–1.36)	76	0.432d	0.83 (0.59–1.18)
P for trende			0.342			0.876			0.199
rs1380576
CC	518	250	0.677c	1.00	141	0.586c	1.00	96	0.539c	1.00
CG	455	238		1.08 (0.87–1.35)	140		1.20 (0.90–1.59)	99		1.35 (0.95–1.92)
GG	106	58		1.15 (0.80–1.65)	34		1.29 (0.82–2.04)	19		1.11 (0.61–2.02)
CG+GG	561	296	0.397d	1.09 (0.89–1.35)	174	0.310d	1.21 (0.93–1.59)	118	0.400d	1.31 (0.93–1.83)
P for trende			0.373			0.154			0.260
rs10900598
GG	296	166	0.279c	1.00	87	0.230c	1.00	54	0.789c	1.00
GT	552	257		0.86 (0.67–1.10)	174		1.02 (0.75–1.40)	114		1.09 (0.73–1.62)
TT	231	123		0.97 (0.72–1.31)	54		0.76 (0.51–1.13)	46		1.02 (0.62–1.65)
GT+TT	783	380	0.210d	0.89 (0.71–1.12)	228	0.948d	0.94 (0.70–1.27)	160	0.508d	1.07 (0.73–1.56)
P for trende			0.738			0.218			0.909
No. of combined
risk genotypesf
0	228	93	0.050g	1.00	71	0.592g	1.00	42	0.621g
1–3	851	453		1.32 (1.00–1.73)	244		0.98 (0.71–1.35)	172		1.23 (0.81–1.87)

^aAdjusted for age, sex, smoking status, and alcohol use in a logistic regression model.

^cTwo-side Chi-square test for the distribution of three genotypes.

^dTwo-side Chi-square test for the distribution of combined genotypes under a dominant model.

^eAdjusted by age, sex, smoking status, and alcohol use.

^fThis represents the number of risk genotypes rs11801299GG, rs1380576CG+GG, and rs10900598GG.

^gTwo-side Chi-square test for the distribution of combined genotypes.