Table 5.
Association of the combined genotypes of MDM4 polymorphisms with stage at presentation of oropharyngeal cancer
| Combined genotypes (no. of risk genotypes)a | T1–2 | T3–4 | ||
|---|---|---|---|---|
| Case (%) / Control (%) | OR (95% CI)b | Case (%) / Control (%) | OR (95% CI)b | |
| 0 | 58 (16.1) / 228 (21.1) | 1.00 | 35 (18.8) / 228 (21.1) | 1.00 |
| 1–3 | 302 (83.9) / 851 (78.9) | 1.40 (1.02–1.94) | 151 (81.2) / 851 (78.9) | 1.16 (0.78–1.73) |
| Combined genotypes (no. of risk genotypes)a | No regional lymph nodes metastasis (N0) | Involvement of regional lymph nodes (N1–3) | ||
|
| ||||
| Case (%) / Control (%) | OR (95% CI)b | Case (%) / Control (%) | OR (95% CI)b | |
|
| ||||
| 0 | 21 (23.9) / 228 (21.1) | 1.00 | 72 (15.7) / 228 (21.1) | 1.00 |
| 1–3 | 67 (76.1) / 851 (78.9) | 0.86 (0.51–1.44) | 386 (84.3) / 851 (78.9) | 1.44 (1.07–1.95) |
| Combined genotypes (no. of risk genotypes)a | Stage I–II | Stage III–IV | ||
|
| ||||
| Case (%) / Control (%) | OR (95% CI)b | Case (%) / Control (%) | OR (95% CI)b | |
| 0 | 9 (19.2) / 228 (21.1) | 1.00 | 84 (16.8) / 228 (21.1) | 1.00 |
| 1–3 | 38 (80.8) / 851 (78.9) | 1.13 (0.54– 2.39) | 415 (83.2) / 851(78.9) | 1.34 (1.01–1.77) |
a
This represents the number of risk genotypes used in the calculation: rs11801299GG, rs1380576CG+CC, and rs10900598GG.
b
Adjusted for age, sex, smoking status, and alcohol use in a logistic regression model.