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. Author manuscript; available in PMC: 2012 Jun 22.
Published in final edited form as: J Am Chem Soc. 2011 May 26;133(24):9311–9319. doi: 10.1021/ja1110514

Figure 1.

Figure 1

(a) Mechanistic proposal for the formation of the thiamin thiazole in B. subtilis. The thiazole synthase (ThiG) reaction product 14 is coupled to HMP-PP 17 to form thiamin phosphate 18. Thz-P 15 and cThz-P 16 are possible intermediates in this coupling reaction. (b) Reactions showing conversion of ThiS by ThiF and NifS into ThiS-COSH 7, glycine oxidase ThiO converting glycine 19 to glycine imine 12 and the oxidation of thiamin phosphate 18 to thiochrome 20.