Table 3.
Age ≥65 years and outcomes in the pre-match cohort
| Outcomes | Events (%) | Absolute risk difference* (%) |
Hazard ratio (95% confidence interval) |
P value | |
|---|---|---|---|---|---|
| <65 years (n = 603) |
≥65 years (n = 603) |
||||
| All-cause mortality | |||||
| Unadjusted | 170 (28%) | 215 (36%) | +8% | 1.34 (1.10–1.64) | 0.004 |
| Multivariable-adjusted | --- | --- | --- | 1.13 (0.90–1.42) | 0.287 |
| Propensity-adjusted | --- | --- | --- | 1.10 (0.88–1.37) | 0.394 |
| Cardiovascular mortality | |||||
| Unadjusted | 151 (25%) | 168 (28%) | +3% | 1.18 (0.95–1.47) | 0.145 |
| Multivariable-adjusted | --- | --- | --- | 0.97 (0.76–1.24) | 0.792 |
| Propensity-adjusted | --- | --- | --- | 0.94 (0.74–1.19) | 0.622 |
| Heart failure mortality | |||||
| Unadjusted | 48 (8%) | 80 (13%) | +5% | 1.77 (1.24–2.54) | 0.002 |
| Multivariable-adjusted | --- | --- | --- | 1.41 (0.93–2.15) | 0.105 |
| Propensity-adjusted | --- | --- | --- | 1.28 (0.88–1.88) | 0.202 |
| All-cause hospitalization | |||||
| Unadjusted | 345 (57%) | 409 (68%) | +11% | 1.30 (1.13–1.50) | <0.001 |
| Multivariable-adjusted | --- | --- | --- | 1.10 (0.94–1.30) | 0.250 |
| Propensity-adjusted | --- | --- | --- | 1.16 (0.99–1.34) | 0.067 |
| Heart failure hospitalization | |||||
| Unadjusted | 203 (34%) | 240 (40%) | +6% | 1.24 (1.03–1.50) | 0.024 |
| Multivariable-adjusted | --- | --- | --- | 1.05 (0.85–1.30) | 0.651 |
| Propensity-adjusted | --- | --- | --- | 1.14 (0.93–1.40) | 0.216 |
*
Absolute risk differences were calculated by subtracting percent events in the <65 year group from the percent events in the ≥65 year group (before rounding)