Skip to main content
. Author manuscript; available in PMC: 2011 Oct 1.
Published in final edited form as: Biosci Rep. 2011 Oct 1;31(5):303–307. doi: 10.1042/BSR20100134

Figure 2. PTPRT-knockout mice are hypersensitive to AOM induces colon tumours.

Figure 2

(A) Schematic of PTPRT targeting strategy. The exon 22, which encoded the phosphatase catalytic motif of PTPRT, was deleted. (B) Southern blotting of genomic DNA from mice with indicated PTPRT genotypes. Arrowhead indicates the targeted alleles. (C) Gross morphology of two tumours (arrowheads) in a PTPRT−/− mouse (right) compared with a colon of a PTPRT+/+ (WT) mouse. (D) Representative images of haematoxylin and eosin staining of AOM-induced tumours. (E). Numbers of colon tumours developed in each of the PTPRT+/+, +/− and −/− C57BL/J6 mice (n = 20 in each group). Each circle, square or triangle represents one mouse. (C) and (E) are reproduced from [12] with permission.