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. 2011 May 10;30(12):2454–2464. doi: 10.1038/emboj.2011.146

Figure 8.

Figure 8

Schematic diagrams depicting the delivery of an initiator tRNA to the P site of a HCV IRES-associated 40S ribosomal subunit under normal and stress conditions. (A) eIF2 delivery of initiator tRNA to the 40S ribosomal subunit under normal conditions. (B) eIF2A delivery of initiator tRNA to the 40S ribosomal subunit under stress conditions. The anticodon of the initiator tRNA is associated with the initiation codon in the mRNA. eIF5B, which may facilitate 60S ribosome joining under normal and stress conditions, is also depicted. eIF5B and the direct interaction between eIF2A and the IIId domain of the HCV IRES may allow proper positioning of the eIF2A-associated initiator tRNA at the P site of the ribosome.