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. 2011 May 20;30(12):2312–2324. doi: 10.1038/emboj.2011.160

Figure 4.

Figure 4

Controlling specific molecular events inside living cells with light. (A) Caging a near-universally conserved lysine (K97) in the MEK1 active site inactivates the enzyme by sterically blocking ATP binding. Decaging with light rapidly removes the caging group and activates the kinase (figures created using Pymol and MEK1 structure PDB: 1S9J). (B) Isolating a synthetic photoactivateable subnetwork in MAP kinase signalling, via genetically encoding a photocaged lysine in the MEK1 active site.