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. 2001 Mar 27;98(7):3970–3975. doi: 10.1073/pnas.071052298

Figure 1.

Figure 1

(A) SP up-regulated HIV Bal replication in MDM. MDM were incubated with different concentrations of SP as indicated and infected with HIV Bal strain. Untreated and HIV-infected MDM were used as an infection control (HIV only). HIV RT activity was determined in triplicates in the culture supernatants 12 days after infection. The data shown are presented as the mean ± SD of triplicate cultures and are representative of three experiments (**, P < 0.01, SP 10−6 M vs. untreated). (B) Effect of CP-96,345 on HIV infection of human MDM. The HIV Bal strain was used to infect MDM in the presence or absence of CP-96,345 (10−8 to 10−6 M). HIV RT activity was measured in the supernatants 8 and 12 days after infection. HIV RT activity in CP-96,345-treated and infected MDM culture supernatants were expressed as percentage of that of untreated and HIV-infected MDM controls.