Figure 4.
Effect of CP-96,345 on HIV replication by antagonism of NK-1R on MDM. HIV Bal strain was used to infect MDM in the presence or absence of CP-96,345 (10−7 M) or CP-96,344 (10−7 M). HIV RT activity was determined in the culture supernatants collected 8 days after infection. RT activity in HIV-infected MDM was used as a positive control (HIV only), whereas that in HIV-infected MDM in the presence of CP-96,344 was used as a specificity control. The data shown are presented as the mean ± SD of triplicate cultures and are representative of three experiments (*, P < 0.05; CP-96,345 vs. HIV only).