Figure 6.
Effect of CP-96,345 on HIV infection of MDM. Different HIV strains were used to infect MDM in the presence or absence of CP-96,345 (10−7 M). HIV RT activity in the culture supernatants was determined 8 days after infection. HIV RT activity in the CP-96,345-treated and HIV-infected MDM were expressed as percentage of that of untreated and HIV (corresponding strains)-infected MDM controls, which were defined as 100%. The data shown are presented as the mean ± SD of triplicate cultures and are representative of three experiments (*, P < 0.05; **, P < 0.01; CP-96,345 vs. HIV only). R5, CCR5 tropic strains; X4, CXCR4 tropic strains; R5X4, dual tropic strains.