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Constitutive induction (Con) and adult induction (Ind) of A1-AR expression in transgenic mice. For adult A1-AR induction doxycycline, (DOX) was removed from transgenic mice at 3 weeks of age (Panel A): HE staining of 6-Week-old mouse myocardium cross-section. (Panel B): Kaplan-Meier survival curves for mice constitutively expressing A1-AR (A1-transgenic construct [TGCon]) and for mice with A1-AR induced at 3 weeks of age by removal of DOX (A1-TGInd).
