TABLE 3.
Leukocyte Integrins are Receptors
| Integrin |
Ligands | ||
|---|---|---|---|
| Common Names | CD Nomenclature | Subunit Structure | |
| Mo1/Mac-1 | CD11b/CD18 | αMβ2 | More than 30, including ICAMs-1, -2, -4; VCAM-1, C3bi, fibrinogen, Factor X, β-glucan; multiple exracellular matrix proteins (fibronectin, vitronectin, laminin, collagens, thrombospondin); multiple proteases (elastase, plasminogen, MMP-9, kininogen); uPAR, Leishmania gp63, Candida albicans, LPS, NIF |
| LFA-1 | CD11a/CD18 | αLβ2 | ICAMs-1, -2, -3, -4. -5; JAM-1 |
| P150,95 | CD11c/CD18 | αXβ2 | iC3b, ICAM-1, fibrinogen, LPS |
| CD11d/CD18 | αDβ2 | Similar to CD11b/CD18 including ICAM-3, VCAM-1, various ECM proteins, plasminogen | |
Abbreviations: ICAM, intercellular adhesion molecule; VCAM, vascular cell adhesion molecule; ECM, extracellular matrix molecules; MMP, matrix metaloproteinase; uPAR, urokinase plasminogen activator receptor; LPS, lipopolysaccharide; NIF, neutrophil inhibitory factor; JAM, junctional adhesion molecule.