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Podocyte plasticity and WTIP function. The podocyte undergoes a remarkable change in morphology in proteinuric kidney diseases. The transcription factor WT1 regulates the podocyte differentiation state. The WT1-interacting protein WTIP can shuttle reversibly from podocyte cell-cell contacts into the nucleus to inhibit WT1 activity and permit podocyte adaption to a disease state. Used with permission (32).
