Fig. 8.

1:1 Relationship between LDL-C reduction and CHD risk reduction maintained between statin and non-statin trials. Estimated change in the 5-year relative risk of non-fatal myocardial infarction or CHD death associated with mean LDL-C reduction (dashed line) along with the 95% probability interval (dotted line). The solid line has a slope = 1. The crude risk estimates from the individual studies are plotted along with their associated 95% confidence intervals. (Reprinted from Robinson JG, Smith B, Maheshwari N, Schrott H. Pleiotropic effects of statins: benefit beyond cholesterol reduction?: A meta-regression analysis, J Am Coll Cardiol 2005;46(10):1855–62. Copyright 2005, with permission from Elsevier.)