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. 2011 May 31;108(24):9747–9752. doi: 10.1073/pnas.1102962108

Fig. 2.

Fig. 2.

(A) Relative binding of FGF2 to the indicated glycosaminoglycan (0.5-, 5-, and 10-μM concentration) on polysaccharide microarrays in the presence (red) or absence (black) of FGFR1. (B) Relative binding of FGFR1 to the indicated glycosaminoglycan (0.5-, 5-, and 10-μM concentration) on polysaccharide microarrays in the presence (red) or absence (black) of FGF2. (C) Relative binding of NGF, BDNF, NT-3, and NT-4/5 to the indicated CS tetrasaccharide on carbohydrate microarrays. (D) Relative binding of the Trk receptors to CS tetrasaccharides on carbohydrate microarrays in the presence (red) or absence (black) of the indicated NTs. (E) Comparison of the relative binding of TrkA to CS-E-enriched polysaccharides in the presence of NGF, NT-3, or NT-4/5. Binding relative to the maximum signal for each plot is shown in A–C and E; binding relative to the maximum signaling for the series of two plots is shown in D. Each protein was analyzed in triplicate, and the data represent an average of 8–10 spots for a given carbohydrate concentration.