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. 2011 May 31;108(24):9798–9803. doi: 10.1073/pnas.1014598108

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Fig. 1. — Self-assembly of analogs of the CXCR4 second transmembrane helix. (A) Transmission electron microscopy of self-assembled X4-2-1 (LLFVITLPFWAVDAVANWYFGNDD). (B) X4-2-9 (FVITLPFWAVDAVANWYFGNDD-(CH₂CH₂O)₂₇-NH₂), just two residues shorter than X4-2-6, self-assembles into fibrils. (C) X4-2-2 (LLFVITLPFWAVDAVANWYFGNKK) assembled into nonuniform nanostructures. (D) Transmission electron microscopy of X4-2-6 (LLFVITLPFWAVDAVANWYFGNDD-PEG27). (E) DLS of X4-2-6, 0.4 mg/mL in PBS reveals remarkable size homogeneity.