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. Author manuscript; available in PMC: 2011 Jun 16.
Published in final edited form as: Science. 2010 Aug 20;329(5994):959–964. doi: 10.1126/science.1190287

Fig. 4.

Fig. 4

Selective NR2B antagonist Ro 25-6981 activates mTOR signaling and produces rapamycin-sensitive behavioral effects. (A, B) Effects of Ro 25-6981 (10 mg/kg, ip) on pmTOR, p4E-BP1, pp70S6K, pERK, pAkt, Arc, synapsin I, PSD95, and GluR1 in prefrontal cortex. (C–D) Pre-treatment with rapamycin (0.2 nmol, ICV) abolished the actions of Ro 25-6981 in FST (C) and NSFT (D). Values represent mean ± SEM (n = 6–8 animals; *P < 0.05; **P < 0.01, ANOVA).