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. Author manuscript; available in PMC: 2012 Apr 1.
Published in final edited form as: Stroke. 2011 Mar 10;42(4):889–896. doi: 10.1161/STROKEAHA.110.591065

Table 5.

Interactions between Unlinked Regions (p ≤ 0.001)

Phenotype Gene P-value*
Thick IL6R, TNFSF4 4.61E-04
IL6R, NOS2A-1 1.03E-04
IL6R, NOS2A-2 1.62E-04
TNFSF4, NOS2A-1 8.80E-06
TNFSF4, NOS2A-2 1.18E-04
TNFSF4, PPARA-1 6.06E-04
NOS2A-1, NOS2A-2 1.34E-04
NOS2A-1, PPARA-1 1.63E-04
NOS2A-1, PPARA-2 3.65E-04
NOS2A-2, PPARA-1 4.42E-04
NOS2A-2, PPARA-2 8.61E-04
Irregular IL1A, PPARA 4.91E-04
Calcified ITGA2, PPARA 3.81E-04
ITGA2, TLR4 7.99E-04
*

p-value from FAMHAP. multiple testing correction has been applied via the minP approach

For thick plaque, analyzed SNPs included rs1386821 for IL6R ; rs1234313 for TNFSF4; rs2297518 and rs3730017 for NOS2A-1; rs8081248 for NOS2A-2; rs4253655 for PPARA-1; and rs6007662, rs4253681, and rs11090819 for PPARA-2. For irregular plaque, analyzed SNPs included rs1800587 for IL1A and rs4253655 for PPARA. For calcified plaque, analyzed SNPs included rs1991013 for ITGA2; rs4253655 for PPARA; and rs752998 and rs1927911 for TLR4.

Full results are in Supplementary Table S4