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. 2001 Mar 27;98(7):3982–3987. doi: 10.1073/pnas.071477498

Figure 4.

Figure 4

Class I colocalizes in MIICs. (A) Ultrathin cryosections of immature CD34-derived LCs were double immunolabeled for MHC class II (rabbit anti-human HLA-DR, small gold) and MHC class I (rabbit anti-heavy chain serum, large gold). PM, plasma membrane. (B–D) Endosomes, double immunolabeled with class I (small gold), together with HLA-DR (large gold) (B), class I (large gold) together with CD63 (small gold) (C), and mannose-6-phosphate receptor (small gold) (D). Large gold particles are 15 nm and small gold particles (arrows) 5 nm; size bars represent 200 nm.