Fig. 6.

Stability of a human breast tumor functional proteomic “fingerprint” despite individual protein variability resulting from intratumoral heterogeneity. This figure shows unsupervised clustering of total and phosphoprotein quantification data obtained by applying reverse phase protein arrays (RPPA) to protein lysates derived from two independent sections obtained from each of 49 human hormone receptor-positive breast cancers. In only six of the 49 cases did the tumor functional proteomic “fingerprints” in each of the two corresponding tumor sections not significantly correlate with each other (at p≤0.05)