. Author manuscript; available in PMC: 2011 Dec 1.

Published in final edited form as: Clin Proteomics. 2010 Dec;6(4):129–151. doi: 10.1007/s12014-010-9055-y

Table 4.

Time-dependent variability in total and phospho (p) protein expression with increasing time to breast tumor freezing

Apoptosis: Cleaved caspase 7, cleaved PARP

Energy sensor pathway: AcCoAp (i.e., phospho-AcCoA), AMPKp, TSC2, TSC2p

Hormonal signaling: ERp167, PR

Phosphatidylinositol-3-kinase (PI3K) pathway: Aktp308, p110 alpha, PTEN

Src-/mitogen-activated protein kinase (MAPK) pathway: MAPKp, p38, p38p180_182, srcp527

Translation: total p70S6 Kinase, S6p235–236

Other: B catenin, COX2, E cadherin, stat3p705

The expression of 21/82 total and phosphoproteins displayed significant (at p≤0.05) time-dependent variability with increasing time to tumor freezing up to 24 h. These 21 proteins are subdivided by function in this table. Of all 82 assessed proteins, the 13 proteins that showed a 40% or greater percentage change from baseline with increasing time to freezing are underlined in this table