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. 2011 Apr 7;2011:297868. doi: 10.1155/2011/297868

Figure 3.

Figure 3

Thymic T cell development. Cartoon diagram of the development of a T cell from a bone marrow-derived hematopoietic progenitor to that of a mature CD4+ or CD8+ T cell capable of mounting an immune response in the periphery. Itk is necessary for both positive and negative selection, as it is able to modulate the strength of signal emanating from the T cell receptor.