Table 1.

Comparison of phenotypes between TCR-inducible signaling molecules. Table depicting developmental, biochemical, and phenotypic defects observed in mice deficient for the indicated gene in the first column. A “Yes” response denotes confirmation of the defect, while “N.A.” indicates “not applicable” and “N.D.” indicates “not determined”. References for the defects are listed in the last column.

	Developmental defects		Biochemical defects								In vivo phenotype defects					Ref.
KO mouse	Stage pre- TCR	Affected	PLCγl phos	Ca++ flux	Erk phos	NFAT activ	IL-2 prod	Proliferation	Actin polym	Adhesion	Activated phenotype	AICD	TH2 response	Pathogen clearance	Eosinophilia
Itk	Mild	DP-SP	Yes	Mild	Yes	Yes	Yes	Mild	Yes	Yes	Yes	Yes	Yes	Yes	Mild	[36, 92, 167, 170, 202, 204, 205]
RIk	No	No	No	No	No	No	Mild	No	No	No	N.D.	N.D.	N.D.	N.D.	N.D.	[92]
Tec	No	No	N.D.	N.D.	N.D.	N.D.	No	No	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	[144]
Itk/Rlk	Yes	DP-SP	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	No	No	N.D.	[92]
Lck	Yes	DN1	Yes	Yes	Yes	Yes	Yes	Yes	Yes	N.D.	N.A.	N.A.	N.A.	N.A.	N.A.	[141]
ZAP-70	Yes	DN3-DN4	Yes	Yes	Yes	Yes	Yes	Yes	Yes	N.D.	N.A.	N.A.	N.A.	N.A.	N.A.	[142, 143]
LAT Y136F	Yes	DN3-DN4	Yes	Yes	No	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Increase	N.D.	Yes	[145–147]
SLP-76	Yes	DN1	Yes	Yes	Yes	Yes	N.D.	Yes	Yes	N.D.	N.A.	N.A.	N.A.	N.A.	N.A.	[148, 149]
Vav1	Mild	DP-SP	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	N.D.	N.D.	Yes	N.D.	N.D.	[107, 108, 158–162]
ItpkB	Yes	DP-SP	Yes	No	Yes	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	[49, 163, 164]
Gads	Yes	DN3-DN4	Yes	Yes	Yes	Yes	Yes	Yes	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	[165]
PLCγl	Mild	DP-SP	Yes	Yes	N.D.	Yes	Yes	Yes	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	[150]
WASp	Mild	No	N.D.	Mild	No	Yes	Yes	Yes	Yes	No	Yes	N.D.	Yes	N.D.	N.D.	[151, 152]
PKCθ	No	No	Yes	Yes	No	Yes	Yes	Yes	Yes	N.D.	N.D.	Yes	Yes	Yes	N.D.	[153–157]
CypA	No	No	No	No	No	Yes	Yes	Yes	N.D.	N.D.	N.D.	N.D.	Yes	N.D.	N.D.	[66, 166]