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Dimerization of ErbB2 receptors leads to phosphorylation and activation of several intracellular catalytic substrates, including the Ras/Raf/MEK/Erk, PI3K/Akt and other important signaling pathways that regulate apoptosis, protein synthesis and cellular proliferation. Our experimental results summarized in this Extra View, demonstrate that ErbB2 signaling activates a Rac-Pak signaling pathway that contributes to ErbB2 mediated transformation through the Erk and Akt pathways.
