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Schematic model for the cooperative interactions of PTEN deficiency and RAS activation. (A) Activated RAS (RAS*) causes RAF/MAPK activation and PI3K/AKT activation, increasing pAKT1 and 3 preferentially. (B) PTEN inactivation and RAS activation cooperates to increase pAKT2 along with pAKT1 and pAKT3.
