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. 2011 Jan-Feb;2(1):41–46. doi: 10.4161/sgtp.2.1.15038

Figure 1.

Figure 1

Three proteins are translated from the C/EBPβ mRNA. Schematic of human C/EBPβ mRNA showing locations of the three in-frame methionines used to initiate translation as depicted below. The basic-leucine zipper DNA binding domain and a S/T rich region are common to all three isoforms, whereas the transactivation domain located in the N-terminal half is only found in C/EBPβ-1 and -2. Ras-dependent phosphorylation sites are indicated and include T235 (rat T189) by ERK1/2 or CDKs,18,25,28 S76 (rat S64) catalyzed by CDK2,18 and S322 (rat S273) mediated by p90RSK.18 Additional Ras-dependent modifications not shown include p-T109 and pS-111 by unknown kinases and monomethylation of R114 (numbering for rat protein).18 Additional kinases known to phosphorylate C/EBPβ include PKA,31 PKC,32 p38,33 Ca2+/calmodulin-dependent kinase,34 and GSK3.35