Table 3.
Frequency of micronucleated cells in untreated breast cancer women and controls with different genotypes.
| Genotype | Breast cancer patients (n = 62) | Controls (n = 62) | P value | ||
|---|---|---|---|---|---|
| Number | CBMN (‰) | Number | CBMN (‰) | ||
| CYP17 | |||||
| TT | 27 | 19 ± 8.9 | 38 | 9.3 ± 6.3 | <.0001 |
| TC+CC | 35 | 18.2 ± 10.5 | 24 | 9.6 ± 5.4 | <.0001 |
| CYP1B1 | |||||
| Val/Val | 17 | 18.7 ± 10.5 | 21 | 6.7 ± 4.1 | <.0001 |
| Val/Leu+Leu/Leu | 45 | 18.5 ± 9.6 | 41 | 10.3 ± 5.9 | <.0001 |
| CYP1A1 | |||||
| TT | 40 | 19.5 ± 10.2 | 53 | 9.9 ± 5.5 | <.0001 |
| TC+CC | 22 | 16.7 ± 9 | 9 | 9.1 ± 5.3 | .001 |
| COMT | |||||
| Val/Val | 21 | 15.2 ± 8.7 | 34 | 11.3 ± 6.7 | .07 |
| Val/Met+Met/Met | 41 | 20.3 ± 10 | 28 | 8.5 ± 4.9 | <.0001 |
MNF: micronucleus frequency; M: mean; SE: standard error; patients compared to controls.