Table 1.

Proteins higher in ET. ET, n=6; SA, n=6; q<0.05. Listed are the 58 spots for which a unique ID was recovered based on criteria summarized in methods. Columns are as follows: master number of spot (spot), average normalized volume ratio of ET to SA (fold), False Discovery Rate-modified p-value for the t-test (q), identification of match (protein ID), official symbol (gene), NCBI GenInfo Identifier (GI), species for this GI (species), molecular mass in Daltons for this GI (Da), number of distinct peptides matched (peps), Spectrum Mill protein score (score), amino acid coverage with ratio of quantity of recovered amino acids over total amino acids in the first column and percent coverage in the second column (AA coverage), possible area of function based on information from NCBI “gene” (functional grouping); Ub, ubiquitin; ER, endoplasmic reticulum; UPR, unfolded protein response; TCA, tricarboxylic acid cycle; ROS, reactive oxygen species; dev, development

spot	fold	q	protein ID	gene	GI	species	Da	peps	score	AA coverage		functional grouping
141	1.53	0.02	oxoglutarate dehydrogenase	OGDH	29145087	mouse	116118	4	58	55/1019	5	TCA cycle, lysine degradation, tryptophan metabolism
151	1.75	0.048	oxoglutarate dehydrogenase-like	OGDH	8922716	human	114480	5	84	76/1010	8	TCA cycle, lysine degradation, tryptophan metabolism
152	1.82	0.012	alpha-ketoglutarate dehydrogenase-like	OGDH	160419019	human	114482	13	207	166/1010	16	TCA cycle, lysine degradation, tryptophan metabolism
157	1.54	0.033	alpha-ketoglutarate dehydrogenase-like	OGDH	160419019	human	114482	7	114	100/1010	10	TCA cycle, lysine degradation, tryptophan metabolism
160	1.56	0.012	fragment: oxoglutarate dehydrogenase	OGDH	90076414	macaque	40206	2	31	22/358	6	TCA cycle, lysine degradation, tryptophan metabolism
168	1.39	0.017	ubiquitin specific peptidase 5 (isopeptidase T)	USP5	74150576	mouse	93355	9	136	109/835	13	Ub mediated protein catabolism, metal ion binding
174	1.61	0.012	ogdh protein	OGDH	29145087	mouse	116118	4	58	55/1019	5	TCA cycle, lysine degradation, tryptophan metabolism
178	1.53	0.02	oxoglutarate dehydrogenase (lipoamide)	OGDH	85861164	mouse	116450	15	220	147/1023	14	TCA cycle, lysine degradation, tryptophan metabolism
252	1.41	0.019	dynamin 1	DNM1	18093102	rat	95928	18	276	201/851	24	receptor-mediated endocytosis
271	1.33	0.045	valosin-containing protein	VCP	30023842	mouse	89364	23	354	303/806	38	caspase activation, ER UPR, protein localization
396	1.29	0.044	aconitase 2, mitochondrial	ACO2	27806769	cow	85358	28	471	314/780	40	TCA cycle, precursor metabolites
406	1.63	0.029	NADH dehydrogenase (ubiquinone) Fe-S protein 1	NDUFS1	67970033	macaque	79549	15	240	186/727	26	ETC, ATP metabolism, apoptosis, ROS metabolism
426	1.92	0.012	N-ethylmaleimide-sensitive factor	NSF	10257494	human	82653	16	251	187/744	25	protein transport, ATP binding, hydrolase activity
430	1.87	0.012	N-ethylmaleimide-sensitive factor	NSF	10257494	human	82653	15	234	170/744	23	protein transport, ATP binding, hydrolase activity
443	1.22	0.038	78 kDa glucose-regulated protein precursor (BiP)	HSPA5	115502217	ground squirrel	72329	19	320	224/654	34	ER overload and glucose response, anti-apoptosis
654	1.16	0.024	chaperonin containing TCP1, subunit 5 (epsilon)	CCT5	194676636	cow	59615	15	241	163/541	30	ATP-dependent protein folding
721	1.38	0.012	dihydrolipoamide dehydrogenase	DLD	75040928	orangutan	54122	11	187	133/509	26	pyruvate, alpha-ketoglutarate dehydrogenase complex
723	1.29	0.018	dihydrolipoamide dehydrogenase	DLD	75040928	orangutan	54122	7	113	90/509	18	pyruvate, alpha-ketoglutarate dehydrogenase complex
752	1.77	0.027	tubulin, alpha 1B	TUBA1B	34740335	mouse	50152	10	178	142/451	31	microtubule-based movement, protein polymerization
756	1.73	0.02	tubulin, alpha 1	TUBA1B	6755901	mouse	50136	15	258	201/451	45	microtubule-based movement, protein polymerization
760	1.26	0.019	chaperonin containing TCP1, subunit 2	CCT2	149632291	platypus	60820	11	177	128/563	23	protein folding, specifically actin and tubulin
764	1.94	0.018	tubulin alpha 6	TUBA1C	14389309	human	49896	12	199	180/449	40	microtubule-based movement, polymerization
819	1.68	0.03	tubulin, beta 2	TUBB2C	4507729	human	49907	15	249	198/445	44	microtubule-based movement, polymerization
838	1.67	0.019	ATP synthase subunit alpha, mitochondrial precursor	ATP5A1	75041057	orangutan	59781	18	283	203/553	37	oxidative phosphorylation
848	1.45	0.014	dihydrolipoamide dehydrogenase-binding protein	PDHX	90075986	macaque	54055	5	72	57/501	11	pyruvate, alpha-ketoglutarate dehydrogenase complex
865	1.97	0.014	ATP synthase, H+ transporting, mitochondrial F1 complex, beta	ATP5B	32189394	human	56560	15	250	198/529	37	oxidative phosphorylation
868	1.79	0.015	ATP synthase, H+ transporting, mitochondrial F1 complex, beta	ATP5B	28940	human	57956	11	194	144/539	27	oxidative phosphorylation
948	1.59	0.023	ubiquinol-cytochrome c reductase core protein I	UQCRC1	194041191	pig	52699	14	225	174/480	36	oxidative phosphorylation, electron transport chain
989	1.46	0.012	Tu translation elongation factor, mitochondrial	TUFM	73958590	dog	63130	14	218	170/583	29	translation in mitochondria
1057	1.61	0.019	N-myc downstream-regulated gene 2 isoform a	NDRG2	73977281	dog	40718	4	55	61/371	16	neurite outgrowth
1058	1.39	0.021	N-myc downstream-regulated gene 2 isoform a	NDRG2	73977281	dog	40718	5	75	67/371	18	neurite outgrowth
1060	1.64	0.012	fragment: 40S ribosomal protein SA (p40)	RPSA	73986556	dog	29778	7	119	89/267	33	cell growth and motility
1082	1.33	0.047	purine-rich element binding protein A	PURA	149269977	mouse	33476	6	88	100/303	33	control of DNA replication and transcription
1104	1.66	0.018	purine-rich element binding protein A	PURA	73949258	dog	42792	4	53	46/404	11	control of DNA replication and transcription
1109	1.56	0.012	arsA arsenite transporter, ATP-binding	ASNA1	73986513	dog	40091	7	102	70/360	19	anion transport
1123	1.62	0.021	creatine kinase, mitochondrial 1B	CKMT1B	57108147	dog	47076	9	137	93/417	22	energy homeostasis
1153	1.44	0.045	NAD+-isocitrate dehydrogenase, alpha subunit	IDH3A	1182011	macaque	36801	9	145	100/340	29	tricarboxylic acid cycle, rate-limiting step
1167	1.38	0.033	guanine nucleotide binding protein, alpha o isoform B	GNAO1	164607137	mouse	40037	3	44	39/354	11	signal transduction, G-protein coupled
1174	1.58	0.044	guanine nucleotide binding protein, alpha o isoform B	GNAO1	164607137	mouse	40037	9	137	110/354	31	signal transduction, G-protein coupled
1176	1.6	0.028	guanine nucleotide binding protein, alpha o isoform B	GNAO1	164607137	mouse	40037	5	80	71/354	20	signal transduction, G-protein coupled
1192	1.19	0.039	serine/threonine kinase receptor associated protein	STRAP	57106953	dog	38533	12	196	181/350	52	RNA splicing, mRNA processing, protein binding
1229	1.99	0.014	gamma-soluble NSF attachment protein	GSNAP	73962213	dog	34588	6	93	69/311	22	intracellular protein transport, Golgi and ER
1268	1.62	0.024	clathrin, light chain (Lca)	CLTA	73971342	dog	27119	2	23	17/248	7	intracellular protein transport
1293	1.54	0.014	G protein beta 1 subunit	GNB1	984553	rat	37393	9	156	106/340	31	signal transduction, G-protein coupled
1351	1.9	0.013	clathrin, light chain (Lca)	CLTA	73953331	dog	23174	3	42	29/207	14	intracellular protein transport
1356	1.61	0.013	N-ethylmaleimide-sensitive factor attachment protein, alpha	NAPA	148232359	cow	33205	9	138	124/295	42	intracellular protein transport, Golgi and ER, brain dev.
1357	1.57	0.013	pyruvate dehydrogenase E1 component beta subunit	PDHB	73985155	dog	37218	4	56	42/341	12	glycolysis, TCA cycle
1404	1.35	0.012	annexin A5	ANXA5	57100553	dog	35944	11	151	143/321	45	anti-coagulation, signal transduction
1419	1.5	0.012	voltage-dependent anion channel 2	VDAC2	90076508	macaque	31607	4	56	43/294	15	anion transport, Eukaryotic porin
1440	1.26	0.037	tropomyosin 3	TPM3	73961103	dog	28760	14	230	90/248	36	cytoskeleton, cell motility
1539	1.25	0.02	endoplasmic reticulum protein 29	ERP29	115495555	cow	28806	3	49	32/258	12	secretory protein processing, ER lumen
1594	1.78	0.029	NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa	NDUFS3	73983298	dog	30158	10	182	110/263	42	ETC, ATP metabolism, apoptosis, ROS metabolism
1639	1.69	0.02	heat shock protein beta-1	HSPB1	85542053	cow	22393	2	35	26/201	13	oxidative protection, cytoskeleton, chaperone
1680	1.42	0.017	NADH dehydrogenase (ubiquinone) flavoprotein 2	NDUFV2	115502498	orangutan	27355	3	52	34/249	14	ETC/ oxidative phosphorylation
1941	1.87	0.029	cofilin 1	CFL1	73983054	dog	16812	7	117	77/149	52	cytoskeleton; actin polymerization
1996	1.59	0.021	eukaryotic translation initiation factor 5A	EIF5A	4503545	human	16832	4	61	54/154	35	protein synthesis and folding (anabolism)
2069	1.26	0.038	transcription elongation factor B (SIII), polypeptide 2	TCEB2	57088081	dog	12564	2	32	21/113	19	transcription, part of ubiquitin ligase complex
2132	1.31	0.045	chain H, Cytochrome Bc1 Complex	UQCRH	4139399	cow	9175	3	43	28/78	36	ETC, mitochondrial respiration