Table 2.
Proteins lower in ET. ET, n=6; SA, n=6; q<0.05. Listed are the 61 spots for which a unique ID was recovered based on criteria summarized in methods. For explanation of columns, please see legend to Table 1, except average normalized volume is ratio of SA to ET (fold); UPR, unfolded protein response; NA, nucleic acid
| spot | fold | q | protein ID | gene | GI | species | MW | peps | score | AA coverage | functional grouping | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 148 | 1.42 | 0.02 | heat shock 70kDa protein 4 isoform 6 | HSPA4 | 114601656 | chimp | 94370 | 48 | 733 | 306/840 | 36 | UPR, ATP binding, nucleotide binding |
| 154 | 1.42 | 0.035 | heat shock 70 kDa protein 4 | HSPA4 | 75061973 | orangutan | 94299 | 15 | 240 | 152/840 | 18 | UPR, ATP binding, nucleotide binding |
| 182 | 1.3 | 0.026 | heat shock 70 kDa protein 4 | HSPA4 | 194208465 | horse | 94749 | 16 | 265 | 223/841 | 27 | UPR, ATP binding, nucleotide binding |
| 245 | 1.28 | 0.019 | brain glycogen phosphorylase | PYGB | 21361370 | human | 96697 | 14 | 206 | 146/843 | 17 | glycogen catabolism |
| 262 | 1.26 | 0.028 | aconitase 1 | ACO1 | 126030781 | rabbit | 98344 | 10 | 154 | 142/888 | 16 | iron homeostasis |
| 318 | 1.22 | 0.029 | aconitase 2, mitochondrial | ACO2 | 40538860 | rat | 85434 | 21 | 344 | 230/780 | 29 | TCA cycle, precursor metabolites |
| 332 | 1.21 | 0.021 | aconitase 2, mitochondrial | ACO2 | 40538860 | rat | 85434 | 24 | 388 | 265/780 | 34 | TCA cycle, precursor metabolites |
| 398 | 1.26 | 0.025 | N-acylaminoacyl-peptide hydrolase | APEH | 149728649 | horse | 81243 | 7 | 102 | 79/732 | 11 | proteolysis, serine-type endopeptidase |
| 546 | 1.13 | 0.046 | heat shock 70 kDa protein 8 | HSPA8 | 123647 | hamster | 70805 | 25 | 424 | 283/646 | 44 | protein folding, UPR |
| 548 | 1.27 | 0.049 | collapsin response mediator protein-2A isoform 2 | DPYSL2 | 149746221 | horse | 73531 | 15 | 241 | 223/677 | 33 | axon guidance, |
| 555 | 1.26 | 0.02 | transketolase | TKT | 67971086 | macaque | 67848 | 8 | 138 | 109/623 | 18 | anabolic precursors, regulation of growth |
| 565 | 1.27 | 0.021 | transketolase | TKT | 75054695 | orangutan | 67897 | 15 | 236 | 216/623 | 35 | anabolic precursors, regulation of growth |
| 602 | 1.25 | 0.029 | aldehyde dehydrogenase 4 family, member A1 | ALDH4A1 | 194207963 | horse | 62073 | 10 | 159 | 128/562 | 23 | arginine, proline, glutamate metabolism |
| 639 | 1.27 | 0.035 | collapsin response mediator protein-2A isoform 2 | DPYSL2 | 149746221 | horse | 73531 | 20 | 348 | 274/677 | 40 | axon guidance |
| 653 | 1.37 | 0.012 | dihydropyrimidinase-like 5 | DPYSL5 | 62822083 | human | 52094 | 9 | 140 | 112/477 | 23 | nervous system dev., cone guidance |
| 662 | 1.37 | 0.017 | dihydropyrimidinase-like 3 | DPYSL3 | 4503379 | human | 61964 | 10 | 139 | 143/570 | 25 | nervous system dev., NA metabolism |
| 679 | 1.24 | 0.012 | dihydropyrimidinase related protein-3 | DPYSL3 | 73949646 | dog | 94582 | 7 | 97 | 84/881 | 10 | nervous system dev., NA metabolism |
| 693 | 1.34 | 0.016 | dihydropyrimidinase related protein-2 | DPYSL2 | 73993705 | dog | 62262 | 13 | 200 | 180/572 | 31 | axon guidance, |
| 890 | 1.47 | 0.048 | galactokinase 2 | GALK2 | 11041513 | macaque | 40195 | 2 | 29 | 25/363 | 7 | galactose metabolism |
| 947 | 1.26 | 0.038 | enolase 2 | ENO2 | 5803011 | human | 47269 | 11 | 178 | 175/434 | 40 | glycolysis |
| 993 | 1.27 | 0.014 | branched chain aminotransferase 1, cytosolic | BCAT1 | 73997380 | dog | 48242 | 3 | 41 | 21/437 | 5 | protein anabolism/ nitrogen metabolism |
| 1112 | 1.29 | 0.029 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | SERPINB1 | 13489087 | human | 42742 | 2 | 33 | 21/379 | 6 | serine protease inhibitor |
| 1127 | 1.35 | 0.035 | guanine nucleotide binding protein | GNAO1 | 164607137 | mouse | 40037 | 6 | 84 | 74/354 | 21 | signal transduction |
| 1131 | 1.23 | 0.035 | aldolase C, fructose-bisphosphate | ALDOC | 74355075 | human | 43010 | 16 | 262 | 174/398 | 44 | glycolysis |
| 1230 | 1.48 | 0.012 | aldolase C | ALDOC | 229506 | rabbit | 39019 | 2 | 30 | 36/361 | 10 | glycolysis |
| 1242 | 1.26 | 0.014 | aldo-keto reductase family 1, member A1 isoform 2 | AKR1A1 | 109020298 | macaque | 36631 | 6 | 101 | 64/325 | 20 | aldehyde catabolism |
| 1248 | 1.22 | 0.018 | dimethylarginine dimethylaminohydrolase 1 | DDAH1 | 57088769 | dog | 31307 | 7 | 112 | 72/285 | 25 | nitric oxide generation |
| 1286 | 1.38 | 0.026 | aldo-keto reductase family 1, member B3 | AKR1B3 | 160707894 | mouse | 35732 | 7 | 103 | 57/316 | 18 | aldose reductase |
| 1305 | 1.41 | 0.027 | malate dehydrogenase 1, NAD (soluble) | MDH1 | 31982178 | mouse | 36468 | 3 | 46 | 31/334 | 9 | upstream of TCA cycle, cytosolic |
| 1306 | 1.35 | 0.043 | malate dehydrogenase 1, NAD (soluble) | MDH1 | 31982178 | mouse | 36468 | 5 | 77 | 67/334 | 20 | upstream of TCA cycle, cytosolic |
| 1312 | 1.38 | 0.024 | malate dehydrogenase 1, NAD (soluble) | MDH1 | 92087001 | mouse | 36511 | 7 | 98 | 75/334 | 22 | upstream of TCA cycle, cytosolic |
| 1318 | 1.37 | 0.012 | lactate dehydrogenase B | LDHB | 4557032 | human | 36639 | 7 | 109 | 86/334 | 26 | glycolysis, pyruvate to lactate |
| 1328 | 1.45 | 0.015 | lactate dehydrogenase B | LDHB | 4557032 | human | 36639 | 16 | 268 | 157/334 | 47 | glycolysis, pyruvate to lactate |
| 1330 | 1.42 | 0.019 | pyridoxal (pyridoxine, vitamin B6) phosphatase | PDXP | 109127253 | macaque | 47912 | 6 | 91 | 69/453 | 15 | glycolysis, catabolism of vitamin B6 |
| 1377 | 1.37 | 0.013 | pirin | PIR | 57111643 | dog | 32150 | 4 | 57 | 43/290 | 15 | transcription |
| 1383 | 1.21 | 0.019 | proteasome 26S subunit, non-ATPase, 14 | PSMD14 | 74004396 | dog | 33384 | 2 | 29 | 23/299 | 8 | protein turnover |
| 1407 | 1.17 | 0.037 | pyridoxal (pyridoxine, vitamin B6) phosphatase | PDXP | 10092677 | human | 31698 | 6 | 89 | 62/296 | 21 | glycolysis, catabolism of vitamin B6 |
| 1472 | 1.27 | 0.012 | 3-hydroxyisobutyrate dehydrogenase | HIBADH | 114612561 | chimp | 30295 | 7 | 120 | 71/287 | 25 | valine catabolism, mitochondrial |
| 1522 | 1.31 | 0.037 | haloacid dehalogenase-like hydrolase domain containing 2 | HDHD2 | 57089151 | dog | 28942 | 3 | 50 | 40/263 | 15 | redox |
| 1538 | 1.24 | 0.022 | chloride intracellular channel 4 | CLIC4 | 7330335 | human | 28772 | 6 | 85 | 70/253 | 28 | membrane potential |
| 1541 | 1.14 | 0.018 | 14-3-3 protein gamma | YWHAG | 71153781 | cow | 28253 | 9 | 144 | 102/247 | 41 | signal transduction |
| 1575 | 2.2 | 0.044 | glutathione S-transferase mu 2 | GSTM2 | 13936373 | guinea pig | 25695 | 5 | 75 | 40/218 | 18 | glutathione-mediated detoxification |
| 1582 | 1.63 | 0.012 | calbindin 2 | CALB2 | 34098931 | mouse | 31373 | 9 | 139 | 93/271 | 34 | calcium ion modulation |
| 1596 | 1.31 | 0.018 | triosephosphate isomerase 1 variant | TPI1 | 62896835 | human | 26713 | 11 | 204 | 158/249 | 63 | glycolysis, pentose phosphate |
| 1646 | 1.35 | 0.017 | ubiquitin carboxyl-terminal esterase L1 | UCHL1 | 114051423 | cow | 28336 | 11 | 182 | 145/252 | 58 | stress response, walking and eating behaviors |
| 1647 | 1.33 | 0.029 | hypoxanthine phosphoribosyltransferase 1 | HPRT1 | 4504483 | human | 24580 | 2 | 27 | 26/218 | 12 | purine metabolism |
| 1662 | 1.35 | 0.018 | protein-L-isoaspartate (D-aspartate) O-methyltransferase | PCMT1 | 67970625 | macaque | 30318 | 3 | 42 | 31/285 | 11 | anabolism, substrate-specific methylation |
| 1683 | 1.26 | 0.037 | Rho GDP dissociation inhibitor (GDI) alpha | ARHGDIA | 31982030 | mouse | 23408 | 5 | 80 | 55/204 | 27 | signal transduction |
| 1768 | 1.17 | 0.037 | glyoxalase I | GLO1 | 134085635 | cow | 20766 | 2 | 21 | 14/184 | 8 | apoptosis/anti-apoptosis |
| 1796 | 1.24 | 0.024 | peroxiredoxin 2 isoform 1 | PRDX2 | 109123569 | macaque | 19470 | 8 | 138 | 80/176 | 45 | redox |
| 1951 | 1.29 | 0.012 | cofilin 2 | CFL2 | 14719392 | human | 18737 | 6 | 98 | 68/166 | 41 | cytoskeleton; actin polymerization |
| 1990 | 1.37 | 0.033 | synuclein, gamma | SNCG | 90110074 | human | 13331 | 3 | 46 | 37/127 | 29 | cell motility, metastasis |
| 1992 | 1.51 | 0.024 | synuclein, gamma | SNCG | 149034108 | rat | 13046 | 6 | 97 | 53/123 | 43 | cell motility, metastasis |
| 1995 | 1.41 | 0.018 | synuclein, gamma | SNCG | 90110074 | human | 13331 | 2 | 30 | 37/127 | 29 | cell motility, metastasis |
| 2002 | 1.23 | 0.024 | peptidylprolyl isomerase A | PPIA | 6679439 | mouse | 17971 | 5 | 75 | 47/164 | 29 | chaperone-dependent protein folding |
| 2017 | 1.28 | 0.025 | peptidylprolyl isomerase A | PPIA | 74146841 | mouse | 17944 | 4 | 59 | 31/164 | 19 | chaperone-dependent protein folding |
| 2020 | 1.19 | 0.045 | peptidylprolyl isomerase A | PPIA | 73962252 | dog | 17969 | 2 | 26 | 18/164 | 11 | chaperone-dependent protein folding |
| 2071 | 1.56 | 0.012 | phosphoprotein enriched in astrocytes 15 | PEA15 | 74006311 | dog | 15781 | 3 | 51 | 27/137 | 20 | apoptosis/anti-apoptosis |
| 2073 | 1.27 | 0.05 | programmed cell death 5 | PDCD5 | 73948546 | dog | 15465 | 2 | 27 | 25/138 | 18 | apoptosis/anti-apoptosis |
| 2085 | 1.6 | 0.024 | phosphoprotein enriched in astrocytes 15 | PEA15 | 74006311 | dog | 15781 | 3 | 46 | 36/137 | 26 | apoptosis/anti-apoptosis |
| 2117 | 1.25 | 0.013 | profilin 2 | PFN2 | 16753215 | human | 15046 | 4 | 59 | 37/140 | 26 | cytoskeleton; actin polymerization |