Table 5.
Functional groupings for proteins found to alter from SA to ET. The official symbols of the genes encoding proteins that differed between SA and hibernating (ET) ground squirrels are listed.
| higher in early torpor | higher in summer active |
|---|---|
|
glycolysis, sugar metabolism
| |
| PYGB | |
| MDH1-cytosolic (3 spots) | |
| ALDOC (2 spots) | |
| TPI1 | |
| ENO2 | |
| LDHB (2 spots) | |
| GALK2 | |
|
pyruvate dehydrogenase complex
| |
| DLD (2 spots) | |
| PDHB | |
| PDHX | |
|
TCA cycle
| |
| ACO2 | ACO2 (2 spots) |
| IDH3A | |
| DLD (2 spots) | |
| OGDH (7 spots) | |
|
intracellular trafficking
| |
| DNM1 | |
| NSF (2 spots) | |
| GSNAP | |
| CLTA (clathrin, 2 spots) | |
| NAPA (alpha SNAP) | |
|
signal transduction
| |
| GNAO1 (3 spots) | GNAO1 |
| GNB1 | YWHAG (14-3-3 gamma) |
| ANXA5 | ARHGDIA |
|
redox
| |
| ACO1 | |
| AKR1A1 | |
| DDAH1 | |
| AKR1B3 | |
| HDHD2 | |
| GSTM2 | |
| TKT (2 spots) | |
| PRDX2 | |
|
ion modulation
| |
| ASNA1 | CLIC4 |
| VDAC2 | CALB2 |
|
cytoskeleton/cell motility
| |
| TUBA1B (2 spots) | DPYSL2 (3 spots) |
| TUBA1C | DPYSL3 (2 spots) |
| TUBB2C | DPYSL5 |
| NDRG2 (2 spots) | CFL2 |
| RPSA | SNCG (3 spots) |
| TPM3 | PFN2 |
| HSPB1 | PDXP (2 spots) |
| CFL1 | |
|
ETC/oxidative phosphorylation
| |
| NDUFS1 | |
| ATP5A1 | |
| ATP5B (2 spots) | |
| UQCRC1 | |
| NDUFS3 | |
| NDUFV2 | |
| UQCRH | |
|
apoptosis/antiapoptosis
| |
| HSPA5 | GLO1 |
| PEA15 | |
| PDCD5 | |
|
protein synthesis and folding (anabolism)
| |
| CCT5 | HSPA4 (3 spots) |
| CCT2 | HSPA8 |
| TUFM | SERPINB1 |
| ERP29 | PCMT1 |
| EIF5A | PPIA (3 spots) |
|
protein and amino acid breakdown (catabolism)
| |
| USP5 | APEH |
| VCP | ALDH4A1 |
| PSMD14 | |
| BCAT1 | |
| HIBADH | |
| UCHL1 | |
|
transcription/nucleic acid processing
| |
| PURA (2 spots) | PIR |
| STRAP | HPRT1 |
| TCEB2 | |