Table 3.
Potency and Curve Class of PXR qHTS Actives
|
Curve classification |
|||||
---|---|---|---|---|---|---|
EC50 (μM) | 1a | 1b | 2a | 2b | 3 | Total |
<1 | 26 | 10 | 0 | 1 | 2 | 39 |
1–10 | 113 | 58 | 65 | 99 | 4 | 339 |
10–100 | 2 | 5 | 101 | 163 | 105 | 376 |
>100 | 0 | 0 | 0 | 0 | 0 | 0 |
Total per classification | 141 | 73 | 166 | 263 | 111 | 754 |
% of library | 2.0 | 1.0 | 2.4 | 3.8 | 1.6 | 10.8 |