Skip to main content
. Author manuscript; available in PMC: 2011 Sep 9.
Published in final edited form as: Chem Rev. 2011 Jan 14;111(3):1846–1913. doi: 10.1021/cr1002744

Table 16.

DcA of α-Ketamine Protected Amino Acid Allyl Esters

graphic file with name nihms297499u14.jpg
entry R1 R2 solvent temp (°C) ligand yield (%)
1 Ph H THF 25 dppf 67
2 Ph Me THF 40 dppf 81
3 Ph Ph THF 40 dppf 75
4 4-F-C6H4 H THF 25 dppb 66
5 4-F-C6H4 Me THF 40 dppb 93
6 4-MeO-C6H4 Me THF 40 dppb 85
7 CH2Ph Me Toluene 110 dppf 63
8 CH2Ph Ph Toluene 110 dppf 46
9 graphic file with name nihms297499t31.jpg H Dioxane 102 dppb 67
10 graphic file with name nihms297499t32.jpg Me Toluene 110 dppf 26