Table 1.
Properties of different botulinum toxin preparations
| Brand name | Botox® | Dysport® | Xeomin® | Myobloc®/Neurobloc®a |
|---|---|---|---|---|
| Generic name | OnabotulinumtoxinA | AbobotulinumtoxinA | IncobotulinumtoxinA | RimabotulinumtoxinB |
| Manufacturer | Allergan Inc (USA) | Ipsen Ltd (UK) | Merz Pharmaceuticals GmbH (Germany) | Solstice Neurosciences Inc (USA) |
| Serotype | A | A | A | B |
| Target SNARE | SNAP-25 | SNAP-25 | SNAP-25 | VAMP (synaptobrevin) |
| Packaging (units/vial) | 100 | 500 | 50, 100 | 2500 (0.5 mL), 5000 (1 mL), 10,000 (2 mL) |
| Pharmaceutical preparation | Powder | Powder | Powder | Ready-to-use solution (5000 U/mL) |
| Stabilization | Vacuum drying | Freeze drying | Vacuum drying | pH reduction |
| Complex size (kDa) | 900 | 300–900 | 150 | 700 |
| Complexing proteins | O | O | X | O |
| Excipients (per vial) | HSA 500 ug | HSA 125 ug | 100 units/vial | HSA 0.5 mg/mL disodium succinate 0.01 M |
| NaCl 900 ug | Lactose 2500 ug | HSA 1 mg | ||
| Sucrose (saccharose) | NaCl 0.1 M | |||
| 4.7 mg | H2O | |||
| Hydrochloric acid | ||||
| Biological activity in relation to Botox® | 1 | 1/3 | 1 | 1/40 |
| Specific activity (units/ng) | 20 | 40 | 167 | 75–125 |
| Storage of packaged product | 2°C–8°C | 2°C–8°C | Room temperature | 2°C–8°C |
| Shelf life | 36 months | 24 months | 36–48 months | 24 months |
| pH of reconstituted preparation | 7.4 | 7.4 | 7.4 | 5.6 |
| Storage once reconstituted | 2°C–8°C for 24 hours | 2°C–8°C for several Hours → 4 hours if stored at room temperature | 2°C–8°C for 24 hours | For a few hours |
Notes:
a
Myobloc® is the brand name in Canada, the United States, and Korea. Neurobloc® is the brand name in the European Union, Norway, and Iceland.
Abbreviations: HSA, human serum albumin; VAMP, veslcle associated membrane protein.