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. 2001 Mar 6;98(7):3998–4003. doi: 10.1073/pnas.051454698

Figure 2.

Figure 2

Analysis of the hypothalamic–pituitary–thyroid axis in the TR-β mutant mice. (a) Schematic diagram of the axis and feedback loop in normal and TR-β mutant animals. The disruption in feedback at the hypothalamic TRH neuron is presumed but is not proven. (b–f) Serum total and free thyroid hormone and TSH levels (mean ± SEM) in serum from male mice at 4 weeks of age, as determined by RIA. +/+, n = 11; mut/+, n = 14; mut/mut, n = 6; TR-β −/+, n = 6. #, Below detection limit. **, P < 0.01 and ***, P < 0.001 vs. +/+ by t testing.