Table 4. Recommendations for the use of resveratrol – part 4.

What valid data are available regarding an effect in various species of experimental animals?
• There is sufficient evidence for a chemopreventive effect of resveratrol on the development of cancer in skin of mice. There are promising results on the prevention of colon cancer in animals. The effects of resveratrol on other cancer types than skin cancer need to be investigated more in detail prior to recommending clinical trials.
• There is sufficient evidence to suggest resveratrol reduces the incidence of hypertension, heart failure, ischemia heart disease in experimental animal models.
• There is sufficient evidence to suggest resveratrol improves insulin sensitivity, reduces blood glucose levels, and reduces high fat diet-induced obesity in rodents.
• Resveratrol showed neuroprotective effects in experimental animal models of injury or degeneration.
• Resveratrol is well tolerated in rats and no toxicological effects are observed up to 700–1000 mg/kg bw/day.