Table 7. Recommendations for research on resveratrol for the coming years.
1 | Clinical studies should be initiated, especially with focus on the effect of resveratrol on the development of cancers in colon and skin |
2 | Clinical studies should be initiated to test the potential cardio-vascular benefit of resveratrol |
3 | Elucidating the biological effects of resveratrol metabolites |
4 | Biodistribution and degradation of resveratrol in vivo, including the role of bacterial enzymes |
5 | Preparation of a resveratrol reference (international standard) product for analytical purposes |
6 | Standardized formulations for clinical studies |
7 | Combinatory effects of resveratrol with other compounds. This include development of relevant models |
8 | Interaction of resveratrol with drug metabolism (especially cytochrome P450 metabolism) |
9 | Identification/development of relevant biomarkers, relevant for the disease-prevention rather than disease treatment, depending on the relevant disease |
10 | Effect of resveratrol on inflammation as general condition relevant for several lifestyle diseases |
11 | Long term preclinical studies in nonhuman primates may be appropriate to determine the effect of resveratrol on diet-induced metabolic disorders, such as development of insulin resistance |