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. 2011 Jun 16;6(6):e20609. doi: 10.1371/journal.pone.0020609

Figure 5. NF-κB activation contributes to rapid inflammasome activation during F. novicida infection.

Figure 5

Macrophages were left untreated or treated with 20 µM of CAPE (NF-κB inhibitor) for 2 h, then infected with F. novicida at an MOI of 100∶1. Supernatants were collected for measurement of cell death by quantifying LDH release (A) and IL-18 secretion (B) at 6.5 h post-infection. Data are representative of four independent experiments. Error bars represent the standard deviation of triplicate samples. *** p≤0.0004, ** p = 0.0074.