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. 2011 Jun 16;6(6):e20919. doi: 10.1371/journal.pone.0020919

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Al-Ghamdi et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(a) We have previously shown that forced expression of Cten induces cell motility. In the reverse experiment, we knocked down Cten protein expression with Cten specific siRNAs (SW620^Cten-) compared with scrambled controls (SW620^ssc). (b) Knockdown of Cten was associated with up-regulation of E-cadherin. (c) Functionally, knockdown of Cten caused reduction in transwell migration (upper panel, p<0.001) and transwell invasion through matrigel (lower panel, p<0.001). (d) Wound healing assays shown delayed closure of wound following Cten knockdown (p<0.001). Upper panel shows wound at time 0 hours and lower panel shows the same field after 72 hours.