Table 1. Genes that elicit broad neuronal defects when knocked-down by RNAi.
| Gene Name | Functional Category | Domain/Function | ASEL | Neurons | Muscle | Gut | Hyp | ASER | ASE |
| tbg-1 | cell/organelle | Tubulin | - | - | + | - | |||
| his-42 | chromosome | Histone H3 | - | - | + | + | - | ||
| zyg-9 | chromosome | Microtubule-associated protein | - | - | + | + | - | ||
| R04F11.3 | chromosome | DNA polymerase subunit Cdc27 | - | - | + | + | ne | ||
| R53.6 | chromosome | DNA replication (GINS complex subunit) | - | - | + | + | - | ||
| his-3 | chromosome | Histone H2A | - | - | + | + | - | ||
| csc-1 | chromosome | Subunit of the Aurora B kinase complex | - | - | + | + | - | - | - |
| his-13 | chromosome | Histone H3 | - | - | + | + | - | ||
| his-4 | chromosome | Histone 2B | - | - | + | - | - | ||
| pole-2 | chromosome | DNA polymerase epsilon, subunit B | - | - | + | - | - | ||
| ran-3 | chromosome | Spindle formation (RCC repeat) | - | - | + | - | - | ||
| gpr-1 | blastomere | G protein regulator (GoLoco motif) | - | - | + | + | - | ||
| mex-3 | blastomere | RNA binding KH domain | - | - | + | + | - | - | ne |
| mex-5 | blastomere | RNA binding CCCH domain | - | - | + | + | - | ||
| gpr-2 | blastomere | G protein regulator (GoLoco motif) | - | - | + | - | - | ||
| T01H3.4 | novel | Transmembrane domains | - | - | + | + | - | ||
| C30B5.4 | RNA reg. | RNA binding RRM domain | - | - | + | - | - | ||
| T09A5.9 | signalling | Regulatory subunit protein phosphatase 1 | - | - | + | + | - | ||
| F19F10.9 | splicing | SART-1 family (U4/U6.U5 snRNP associated protein) | - | - | + | + | - | ||
| M03C11.7 | splicing | Pre-mRNA processing factor 3 | - | - | + | - | |||
| D1054.14 | splicing | PRP38-like splicing factor | - | - | + | - | - |
See Materials and Methods for a detailed description of scoring criteria. Abbreviations: ne, not embryonic lethal.