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. 2011 Jun 16;7(6):e1002109. doi: 10.1371/journal.pgen.1002109

Table 2. Genes that elicit ASE cell/lineage defects when knocked-down by RNAi.

Gene Name Functional Category Domain/Function ASEL >2 ASEL ASER >2 ASER ASE >2 ASE Viable ASE lineage phenotype Mutant phenotype
lis-1 cell/organelle WD40 - wt +/− Loss ASEL
lrg-1 chromosome let-99 related (pseudogene) + +/− + + ectopic ASEL1
par-3 blastomere PDZ domain + + + + + ectopic ASEL1
mei-2 blastomere Microtubule regulator (similar to katanin) + - +/− + ectopic ASEL2
par-2 blastomere RING finger + + - ne ectopic ASEL2 Yes
lit-1 blastomere Serine/threonine kinase (Wnt signalling) - + + + + ectopic ASER
pie-1 blastomere Zinc finger, CCCH-type + + - + + ectopic ASEL2
ced-3 signalling Caspase + + + + + Yes ectopic ASEL1 Yes
oac-35 signalling Integral membrane O-acyltransferase + + - ne ectopic ASEL2
wwp-1 signalling E3 ubiquitin ligase + + + +/− + ectopic ASEL1
ref-1 transcription bHLH + wt + + Yes ectopic ASEL Yes

See Materials and Methods for a detailed description of scoring criteria. Abbreviations: ne, not embryonic lethal; wt, wildtype.

1

also ectopic ASER lineage.

2

also loss of ASER lineage.