. Author manuscript; available in PMC: 2011 Jun 16.

Published in final edited form as: Intensive Care Med. 2010 Mar 13;36(6):963–970. doi: 10.1007/s00134-010-1851-3

Table 5.

Associations between pulmonary versus nonpulmonary infection and 60-day mortality of acute respiratory distress syndrome

	Survivors (n = 337)	Nonsurvivors (n = 212)	ARDS mortality (%)	Adjusted HR(95% CI)^a	P value
Pulmonary infection	210	123	36.9	1.0
Nonpulmonary infection	77	48	38.4	1.26 (0.87–1.85)	0.226
Combined pulmonary and nonpulmonary infections	50	41	45.1	1.69 (1.14–2.49)	0.008

ARDS infection-related acute respiratory distress syndrome, HR hazard ratio, CI confidence interval

Multivariate Cox regression analyses stratified by calendar year, adjusted for age, gender, ethnicity, APACHE III score, body mass index, bacteremia, liver cirrhosis/failure, metastatic/hematological malignancies, pre-ICU stay ≥48 h, PEEP level used on the first day of ARDS diagnosis, vasopressors used on the first day of ARDS diagnosis, and treatment with activated protein C