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Prostacyclin I2 (PGI2) given intravenously nonselectively dilates the pulmonary vasculature and may worsen ventilation/perfusion matching. In contrast, inhaled PGI2 may improve ventilation/perfusion matching by improving pulmonary blood flow to well-ventilated regions of the lung. PAP, pulmonary artery pressure; MAP, mean arterial pressure; Qs/Qt, intrapulmonary shunt. Reprinted with permission from Max and Rossaint (23).
