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. Author manuscript; available in PMC: 2012 Jun 15.
Published in final edited form as: Cancer Res. 2011 May 3;71(12):4074–4084. doi: 10.1158/0008-5472.CAN-10-3968

Figure 1.

Figure 1

AZD8055 plus αCD40 inhibited Renca tumor development in liver. A, In vitro MTS proliferation assay for Renca cells. Renca cells were stimulated with αCD40 (100ug/ml), AZD8055 (AZD) (50ng/ml) or both for 72 hours. For the in vivo tumor model study, Renca cells were injected intrasplenically. Splenectomies were done on all mice immediately after tumor injection. αCD40 (65 ug, i.p.) and AZD8055 (20mg/kg weight, oral gavage) were administered on the indicated days as shown in (B). C, All mice were then euthanized on day 17, and liver tumor nodules were counted. All data are representative of two or three independent experiments.