Table 4.
Results of external cross-validation
| NP-only |
sMRI-only |
Combined NP-sMRI |
|||||
|---|---|---|---|---|---|---|---|
| SZ | HC | SZ | HC | SZ | HC | ||
| STP-LDA | Predicted SZ | 20 | 9 | 18 | 11 | 18 | 8 |
| Predicted HC | 8 | 38 | 10 | 36 | 10 | 39 | |
| Sensitivity (CI)% | 71.4 (51.3–86.8) | 64.3 (44.1–81.4) | 64.3 (44.1–81.4) | ||||
| Specificity (CI)% | 80.9 (66.7–90.9) | 76.6 (62.0–87.7) | 83.0 (69.2–92.4) | ||||
| Accuracy (CI)% | 77.3 (66.2–86.2) | 72.0 (60.4–81.8) | 76.0 (64.8–85.1) | ||||
| Positive likelihood ratio (CI) | 3.73 (2.10–6 .41) | 2.75 (1.57–4.65) | 3.78 (2.00–7.12) | ||||
| Negative likelihood ratio (CI) | 0.35 (0.21–0.59) | 0.47 (0.29–0.73) | 0.43 (0.28–0.66) | ||||
| Odds ratio (CI) | 10.56 (3.58–31.14) | 5.89 (2.17–16.25) | 8.77 (3.01–25.59) | ||||
| χ2 (p) | 20.22 (7× 10−6) | 12.36 (4× 10−4) | 17.31 (3× 10−5) | ||||
| PCA-LDA | Predicted SZ | 22 | 4 | 19 | 13 | 25 | 3 |
| Predicted HC | 6 | 43 | 9 | 34 | 3 | 44 | |
| Sensitivity (CI)% | 78.6 (59.1–91.7) | 67.9 (47.7–84.1) | 89.3 (71.8–97.8) | ||||
| Specificity (CI)% | 91.5 (79.6–97.6) | 72.3 (57.4–84.4) | 93.6 (82.5–98.7) | ||||
| Accuracy (CI)% | 86.7 (76.8–93.4) | 70.7 (59.0–80.6) | 92.0 (83.4–97.0) | ||||
| Positive likelihood ratio (CI) | 9.23 (4.16–21.55) | 2.45 (1.47–3.87) | 13.99 (6.02–32.00) | ||||
| Negative likelihood ratio (CI) | 0.23 (0.14–0.40) | 0.44 (0.26–0.73) | 0.11 (0.05–0.25) | ||||
| Odds ratio (CI) | 39.42 (10.35–149.36) | 5.52 (2.02–15.10) | 122.22 (23.99–622.85) | ||||
| χ2 (p) | 38.03 (7× 10−10) | 11.6 (7× 10−4) | 51.5 (7× 10−13) | ||||
CI, 95% confidence intervals for sensitivity, specificity and accuracy calculated based on the binomial theorem p, p-values