Table 1.

Dorsal Striatum Tissue Levels of Dopamine (DA) & metabolites (DOPAC, HVA). Serotonin (5-HT) & metabolite 5-Hydroxyindoleacetic acid (5HIAA) and turnover ratios in 12 month old WT and Gdnf^+/− male mice.

	Striatal Region	DA (ng/g)	DOPAC (ng/g)	HVA (ng/g)	DOPAC: DA	HVA: DA	(DOPAC +HVA): DA	5-HT (ng/g)	5-HIAA (ng/g)	5-HIAA:5-HT
WT	AP: +1.0	19509±141	3198±73	2087±29	0.164±0.011	0.107±0.004	0.272±0.014	874±10	590±6	0.680±0.030
Gdnf+/−	AP: +1.0	15749±1044*	2907±250	2050±96	0.184±0.007	0.132±0.005*	0.316±0.010*	854±51	635±19	0.757±0.043
WT	AP: +0.1	8656±253	1796±47	1359±25	0.210±0.010	0.162±0.011	0.372±0.019	903±23	653±17	0.726±0.025
Gdnf+/−	AP: +0.1	6026±924*	1487±244	1297±61	0.244±0.011*	0.222±0.010*	0.466±0.010*	867±53	755±56	0.879±0.053*

^*p < 0.05, WT versus Gdnf^+/−, same striatal region

Values shown are mean ± SEM