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. Author manuscript; available in PMC: 2013 Jul 1.
Published in final edited form as: Neurobiol Aging. 2010 Dec 23;33(7):1485.e1–1485.e8. doi: 10.1016/j.neurobiolaging.2010.10.004

Figure 4. Effect of SNP rs7945931genotypes on human total SORL1-mRNA expression levels in human temporal cortex.

Figure 4

Individuals were genotyped for SNP rs7945931 and fold levels of human total SORL1-mRNA were assayed by real-time RT-PCR using TaqMan technology and calculated relative the geometric mean of SYP- and ENO- mRNAs reference control using the 2−ΔΔCt method. Analysis of the temporal cortex showed that the minor allele carriers ‘+A’ genotypes (AA, AG; n=10) correlate with significantly higher total SORL1-mRNA levels then the non carrier, ‘−A’ genotype (GG; n=41) (p=0.008). The same significant trend was observed in the analysis of SNP rs2298525 (p=0.01).